New approaches in diagnosing renal allograft rejection

numares HEALTH investigated the mechanisms in connection with kidney transplant rejection. The research in this field aims to develop an AXINON® test system able to early and reliably display a rejection reaction.

 

A kidney transplantation is the treatment of choice for patients with terminal renal disease. However, the transplanted kidney can often fail due to rejection(1-3). Such a reaction can develop quickly and early detection is difficult. A needle biopsy is usually performed to confirm the diagnosis - an invasive procedure. New approaches in diagnosis are therefore urgently needed.


With the development of a new method based on metabolic profiles for the detection of rejection tendencies in urine, numares HEALTH is pursuing a promising approach. The retrospective study has been completed*. The evaluation of the prospective study UMBRELLA is in progress.

 

Information about AXINON® renalTX-SCORE®-U100

 

*data not published yet

Highlights of a novel AXINON® test for detecting renal allograft rejection

  • based on the analysis of urine by NMR
  • uses metabolic profiles instead of single biomarkers
  • provides fast and cost-effective results
  • shows promising data in a retrospective study
  • performance is currently examined in a prospective study

Shorter life of the graft due to episodes of acute rejection

Episodes of acute rejection are a major risk factor for chronic graft failure4). If an acute graft rejection is detected in time, it can be successfully treated. The symptoms show within days or even weeks. Close monitoring is therefore recommended.

How can an acute rejection episode be detected?

In some patients, unspecific symptoms like tiredness, headaches or nausea can be observed, whilst in others the reaction is less apparent. Laboratory parameters such as creatinine clearance and cystatin C are only of limited relevance. A biopsy is currently the gold standard for confirming the diagnosis.


A reliable, non-invasive test for the early detection of graft rejection would mean additional reassurance and quality of life for patients with their new kidney.

1) Improved graft survival after renal transplantation in the United States, 1988 to 1996 Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. NEJM 2000 Mar 2; 342 (9) :605-612.
2) German Organ Transplantation Foundation (DSO) annual reports. Available at www.dso.de/servicecenter/downloads/jahresberichte-und-grafiken.html, accessed on Nov 20, 2014.
3) Organ Procurement and Transplantation Network (OPTN). www.usrds.org/2014/view/v2_06.aspx, accessed on Nov 20, 2014..
4) Joosten SA et al. Chronic renal allograft rejection: Pathophysiologic considerations. Kidney International (2005) 68, 1–13.